GMP KILO LAB FOR HIGH CONTAINMENT API PRODUCTION

GMP kilo lab for
high Containment
API production

Highly efficient and
environmentally sustainable we
produce small quantities of API
up to level OEB 6 under GMP.

Small batch sizes for early clinical phases or toxicological
studies
Straightforward upscaling of processes
One team to support your active pharmaceutical ingredients – from development up to large-scale production
One Stop Shop, all-embracing from the active pharmaceutical ingredients to the solid dosage market presentation

Dr. Jürgen Bank, Managing Director at Excella

With this investment
in the high containment
area at Excella

we are closing the last gap for an all-embracing
One Stop Shop offer to our customers.

Dr. Jürgen Bank, Managing Director at Excella

For more than 50 years we have been developing and optimizing chemical processes.

Turning laboratory syntheses into sustainable technical processes – that‘s what we are experienced with. With the Kilo Lab we now have exactly the right tool for a first scale-up.

Dr. Axel Huwe, Chemical Process Development

Straightforward
upscaling from
laboratory to
commercial scale

The GMP Kilo Lab, with two glass reactors and one
Hastelloy reactor, exactly mimics our pilot plant
and our large-scale production. This enables a
straightforward and fast transfer or scale-up.

Capabilities and
technical data

Isolator technology to handle
up to OEB 6 (< 100 ng/m3)
Batch sizes of 0.5 – 2 kg API
2 Glass reactors and 1 Hastelloy reactor (10 l)
Temperature range: -30°C to 160°C
Product isolation via filter and tray dryer
Packaging in PE/CurTecTM
State-of-the-art process development (PAT, DOE)

Potential
syntheses

Friedel-Crafts acylation, Grignard reactions, chlorinations
(Cl2, SOCl2, POCl3), alkylations (N, O and C) / dealkylations,
Wittig-Horner-Emmons olefination, oxidations / reductions,
aminations, Corey-Chaykovsky epoxidation, Hofmann
degradation, Reformatsky reaction, C-C coupling reactions,
(transfer) hydrogenations, Gewald reaction
and many more